Publications by authors named "M V Rademaker"
Recent interest in the diverse ecosystem of bacteria, fungi, parasites, and viruses that make up the skin microbiome has led to several studies investigating the microbiome in healthy skin and in a variety of dermatological conditions. An imbalance of the normal skin flora can cause some skin diseases, and current culture techniques are often unable to detect a microorganism to further our understanding of the clinical-microbiological correlates of disease and dysbiosis. Atopic dermatitis and rosacea are presentations that GPs often manage that may have an infective or microbiological component and can be challenging to treat.
View Article and Find Full Text PDFBackground: LCZ696 (sacubitril/valsartan) antagonizes the renin-angiotensin system while simultaneously augmenting the natriuretic peptides (NPs). Inhibition of phosphodiesterase 9 inhibition (PDE9i), which hydrolyses NP-generated cGMP may be a more specific means of enhancing NP bioactivity. The objective of the present study was to compare for the first time effects of LCZ696 and PDE9i+valsartan in experimental heart failure (HF) and investigate combination PDE9i+LCZ696.
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- Current treatment recommendations for atopic dermatitis (AD) may not adequately address patients' needs and goals, prompting the development of new strategies for management.
- An international team of dermatology experts created the Aiming High in Eczema/Atopic Dermatitis (AHEAD) recommendations, incorporating patient input and utilizing a modified voting process to achieve consensus on treatment targets.
- The AHEAD approach emphasizes shared decision-making with patients selecting troublesome symptoms while clinicians assess severity; it aims for minimal disease activity as a goal, achieving significant agreement among experts on the proposed guidelines.
Osteocrin (OSTN) is an endogenous protein sharing structural similarities with the natriuretic peptides [NPs; atrial (ANP), B-type (BNP) and C-type (CNP) NP], which are hormones known for their crucial role in maintaining pressure/volume homeostasis. Osteocrin competes with the NPs for binding to the receptor involved in their clearance (NPR-C). In the present study, having identified, for the first time, the major circulating form of OSTN in human and ovine plasma, we examined the integrated haemodynamic, endocrine and renal effects of vehicle-controlled incremental infusions of ovine proOSTN (83-133) and its metabolism in eight conscious normal sheep.
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- * Data from 112 patients revealed high scores for pruritus, disease severity, and quality of life issues, with many patients reporting inadequate control of their condition.
- * The findings indicate that AD significantly affects various aspects of life for ANZ patients, suggesting a need for improved treatment options.