Publications by authors named "M V Planutiene"
Article Synopsis
- This study examined the effects of soy isoflavones (genistein and ME-143) and two chemotherapy drugs (5-fluorouracil and oxaliplatin) on WNT signaling in colon cancer cells.
- ME-143 was found to be a significantly more effective inhibitor of cancer cell growth compared to genistein, particularly in the DLD1 cell line, while chemotherapy drugs showed variable effects on WNT signaling depending on the cell type.
- The findings suggest that ME-143, especially when used with traditional chemotherapy, could be a promising treatment strategy for colorectal cancer by directly inhibiting the WNT/β-catenin pathway, indicating the need for further clinical research.
A diet rich in fruits and vegetables, and a grape-derived compound, resveratrol, have been linked to a reduced incidence of colon cancer. In vitro and in vivo, resveratrol suppresses Wnt signaling, a pathway constitutively activated in over 85 % of colon cancers.Thirty participants were placed on a low resveratrol diet and subsequently allocated to one of three groups ingesting 1/3-to-1 lb (0.
View Article and Find Full Text PDFNorrin binds to the frizzled-4 receptor, stimulating canonical Wnt signaling. We investigate here the role of colorectal cancer (CRC) produced Norrin in endothelial cell growth, motility, and blood vessel formation, as well as the expression of the Norrin signaling pathway components in the CRC tumor microenvironment. Norrin conditioned medium produced by CRC cell line CaCO2 transfected with Norrin expression construct increased endothelial cell motility.
View Article and Find Full Text PDFBackground: Wnt signaling in the colon cancer tumor microenvironment (TME) may affect cancer biologic properties including invasion and metastatic dissemination. Prior reports have suggested that the expression of select frizzled (Fz) receptors may be altered in cancers and in the TME.
Methods: Colon cancer, colonic adenoma and normal colonic mucosal specimens were obtained under institutional review board approval and analyzed for the expression of Fz1 and Fz2 by confocal fluorescent immunohistochemistry and Wnt-specific membrane array.