New Tripeptide Derivatives Asperripeptides A-C from Vietnamese Mangrove-Derived Fungus LM.5.2.

Three new tripeptide derivatives asterripeptides A-C (-) were isolated from Vietnamese mangrove-derived fungus LM.5.2.

Deep-Sea Anemones Are Prospective Source of New Antimicrobial and Cytotoxic Compounds.

The peculiarities of the survival and adaptation of deep-sea organisms raise interest in the study of their metabolites as promising drugs. In this work, the hemolytic, cytotoxic, antimicrobial, and enzyme-inhibitory activities of tentacle extracts from five species of sea anemones (Cnidaria, orders Actiniaria and Corallimorpharia) collected near the Kuril and Commander Islands of the Far East of Russia were evaluated for the first time. The extracts of and demonstrated maximal hemolytic activity, while high cytotoxic activity against murine splenocytes and Ehrlich carcinoma cells was found in the extract of .

New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus KMM 4689.

Seven new deoxyisoaustamide derivatives (-) together with known compounds (-) were isolated from the coral-derived fungus KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations.

Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of and Genera.

Low molecular weight secondary metabolites of marine fungi , and sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques.

Piltunines A-F from the Marine-Derived Fungus KMM 4668.

Six new carotane sesquiterpenoids piltunines A-F (-) together with known compounds (-) were isolated from the marine-derived fungus KMM 4668. Their structures were established using spectroscopic methods. The absolute configurations of - were determined based on circular dichroism (CD) and nuclear Overhauser spectroscopy (NOESY) data as well as biogenetic considerations.