Publications by authors named "M V Phadke"
Article Synopsis
- The study aims to analyze the epidemiology of cluster headaches (CH) using Veterans Health Administration (VHA) Electronic Health Record data, highlighting the challenges of population-level studies due to the low prevalence of CH (~0.1%).
- Utilizing VHA data from 2008 to 2019, the research identifies over 24,000 patients diagnosed with CH, revealing a one-year prevalence of 0.08% to 0.10% for women and 0.10% to 0.18% for men.
- Findings show a higher prevalence of unspecified CH among women, with many patients also experiencing comorbid conditions like migraine, depression, and other pain diagnoses, emphasizing the complexity of CH cases within the
Article Synopsis
- A retrospective study analyzed metabolic differences between pure and impure uric acid kidney stone formers using data from patients at Yale Urology and Nephrology Clinics between 1996 and 2021.
- Among 722 uric acid stone formers (16.8% of the total), pure stone formers were generally older, heavier, and had a higher incidence of chronic kidney disease.
- The study found that pure uric acid stone formers had lower urinary pH and citrate levels, along with higher protein intake markers, indicating that adjusting protein consumption might help lower the risk of stone formation, especially in those with kidney issues.
Objective: To determine if mild-moderate hypertriglyceridemia (HTG) is associated with increased development of chronic pancreatitis (CP) or pancreatitis-associated complications in children with acute recurrent or CP.
Study Design: Longitudinal data from the INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2 (INSPPIRE-2) cohort of children with acute recurrent or CP (n = 559) were analyzed. Subjects were divided into normal triglycerides (<150 mg/dL; 1.
Adipocyte is a predominant component of the omental adipose tissue that influences the tumor microenvironment and increases the risk of endometrial cancer progression (EC), however, little is known about the underlying mechanism. In this study, using a co-culture model, we found that the adipocyte-EC cell interaction promoted SIRT1 signaling in vitro and in vivo xenograft mice models. Furthermore, immunostaining of SIRT1 protein showed significantly higher expression of SIRT1 in endometrial cancer patients than in normal endometria.
View Article and Find Full Text PDFImportance: Open burn pits have commonly been used for waste disposal by the US military but have not been systematically investigated as an independent risk factor for headache disorders.
Objective: To evaluate the association between exposure to open burn pits and incidence of headache and migraine.
Design, Setting, And Participants: This retrospective cohort study used data from the Veterans Health Administration Headache Cohort along with data from the US Department of Defense and the Airborne Hazards and Open Burn Pit (AH&OBP) Registry to assess registry participants with potential exposure to open burn pits in the Veterans Health Administration from April 1, 2014, through October 31, 2022.