Differences in the consumption rates and regulatory barriers to the accessibility of strong opioid analgesics in Israel and St. Petersburg.

Objective: To compare trends in opioid consumption in Israel and St. Petersburg/Russia (morphine, oxycodone, pethidine, fentanyl, methadone, buprenorphine, trimeperidine, and papaveretum) over the period 2000-2008, and to describe the regulatory barriers to their accessibility as an exploratory variable for between-country differences.

Methods: Data were drawn from the databases maintained by the Israel Ministry of Health's Pharmaceutical Administration and the St.

[Analgesic effects of lornoxicam in formalin-induced inflammation].

Peroral administration of lornoxicam, a new representative of the class of oxicams, in a total dose of 2-16 mg/kg produced a dose-dependent analgesic effect in rats with formalin-induced tail inflammation, as confirmed by the tail-flick and hot-plate tests. The maximum analgesic effect of lornoxicam during the formalin-induced edema development was observed upon a three-fold drug administration by the scheme 1/2, 1/4, 1/4 of the total dose (8-16 mg/kg, p.o.

[A clinical-experimental study of narcotic properties of opiate receptor agonists-antagonists and experience in their use in drug addiction practice].

Narcogenic characteristics of opiate agonists-antagonists were studied in drug abusers. It is shown that buprenorphine, butorphanol, nalbuphine hydrochloride, but not tramadol, have high narcogenic potential. Opportunities for these drugs in narcological practice are outlined.

Isradipine is able to separate morphine-induced analgesia and place conditioning.

The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.