[IDENTIFICATION OF CAUSES OF EARLY PREGNANCY LOSSES ACCORDING TO HYSTOMORPHOLOGIC FEATURES].

Retrospective analysis of the early spontaneous abortions has been conducted (486 cases). Histomorphologic analysis of the curettage material contents erveledinvolutive-regressive developmental chsnges in 108 (22,28%) cases, in 370 cases (77.78%) pathologic changes, like inflammatory changes of deciduas and chorionic villis in 302 cases (80.

[Morpho-functional parameters of the corpus luteum in healthy women and in patients of reproductive age with uterine myoma].

Ovarian corpus luteum of menstruation at the stage of its peak activity was studied in normal women and in patients with proliferative uterine myoma using ultrasonography (intravaginal color Doppler imaging), laboratory analyses (progesterone and estrogen concentrations in peripheral blood) and morphological (histological, histochemical and morphometric) methods. In patients with proliferative uterine myoma, the defective corpus luteum was detected, as indicated by the prevalence of small granulosa lutein cells, insignificant amount and uneven distribution of lipid inclusions in their cytoplasm, marked reduction of progesterone concentration in peripheral blood, unechogenicity, low degree of vascularization and increase in the value of resistance index of ovarian stromal arteries.

[The morpho-functional changes of the follicular apparatus and yellow body of the ovary in women of the reproductive age with myoma].

It have been studied the morpho-functional changes of the ovaries in women of reproductive age with proliferative myoma of uteri. Based on the analysis of the result of the investigation on the myomatic knots of the women in the condition of high activity of proliferation of myocytes a very complexes, multifactorial pathogenetic mechanisms of the myoma has been outlined. Switch in the common changes in the dynamic oxidative stress and hyperestrogenemia promotes development of the myoma.

Morphofunctional characteristics of the ovaries in proliferative uterine myoma.

Morphofunctional changes in the ovaries in women of reproductive age with proliferative uterine myoma were studied. Disorders in folliculogenesis with primordial follicles degeneration of different degree, cystic degeneration of follicles at different stages of their development, paralleled by hyperplasia of the theca-granulosa complex and hyperestrogenemia, were detected. Morphological equivalent of hyperestrogenemia is increased content of lipid inclusions in granulosa cells, ultrastructural hyperplasia, increased volume and quantity of secretion-containing Cull-Exner bodies.

[Effectiveness of radioprotective action of plaferon LB].

The aim of the study was the investigation of effectiveness of radioprotective action of plaferon LB on rat's ovary during gamma-irradiation. It was established that during irradiation in the rats ovary the mechanisms of follicle genesis ovulation and luteinization are disordered. It was revealed hyperplasia of hormone produced structures by way of thekomatosis.