Publications by authors named "M V O'Shaughnessy"
While leg ulceration is common, data regarding long-term is limited. Historical data indicate that approximately 50% of leg ulcer patients die within 5 years of presentation. However, little is known regarding survival outcomes in contemporary patient populations.
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- The term atypical hemolytic uremic syndrome (aHUS) originated in the 1970s to differentiate between familial/sporadic cases and typical epidemic cases associated with Shiga toxin.
- Over time, aHUS has become a broad term for various diseases that don't relate to Shiga toxin, complicating the definition and treatment strategies due to its diverse causes.
- A group of experts used a consensus-building method called the Delphi approach to discuss and clarify the terminology and issues surrounding aHUS in light of advancements in medical science and targeted therapies.
Article Synopsis
- Immunosuppressive treatment for rheumatic diseases helps maintain remission but raises infection risk and diminishes response to SARS-CoV-2 vaccination.
- The study evaluated immune responses to SARS-CoV-2 in two patient groups: one during acute infection and one post-vaccination, comparing results among those exposed to rituximab, other immunosuppressive treatments, and non-immunosuppressed individuals.
- Results showed that while non-immunosuppressed patients had stronger T cell responses during infection, those on immunosuppression had reduced activation, with rituximab-treated patients showing preserved T cell responses but poor antibody production post-vaccination.