Participation of PKG and PKA-related pathways in the IFN-γ induced modulation of the BK channel activity in human cardiac fibroblasts.

This study was devoted to elucidating the interferon (IFN)-γ-induced signaling pathway and the interaction between protein kinase G (PKG) and protein kinase A (PKA) through large-conductance Ca(2+)-activated K(+) channels in human cardiac fibroblasts. The I currents were recorded using a whole-cell patch clamp method. A large depolarization (+50 mV) and a high Ca concentration (pCa 6.