Publications by authors named "M V Mattson"
The catabolic - anabolic cycling hormesis model of health and resilience.
Ageing Res Rev
December 2024
A major goal of aging research is to identify ways of extending productive and disease-free lifespans. Here we present the catabolic - anabolic cycling hormesis (CACH) model for optimizing health. The CACH model is based on the concept that cells and organ systems respond to catabolic challenges in ways that bolster their resilience and that an anabolic recovery period is required to effectuate the benefits of the catabolic challenge.
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- The study explores the use of a data logger to accurately measure standing time and seat angle in individuals using standing devices, specifically for those with spinal cord injuries (SCI).
- Testing involved a standing frame and a standing wheelchair, comparing the data logger's measurements to a user-recorded log and motion capture data over two months.
- Results showed the data logger had exceptional accuracy (99.99999%) for standing classification and a strong correlation with seat angle and pressure measurements, suggesting it could help improve understanding of standing device effectiveness in health outcomes.
Article Synopsis
- Tau hyperphosphorylation and accumulation in neurofibrillary tangles are linked to cognitive decline in Alzheimer's disease, with GSK3β overexpression playing a key role.
- A new GSK3β inhibitory peptide (GIP) was developed, combining motifs from LRP6 and a sequence targeting Akt, effectively blocking tau phosphorylation and reducing cell death.
- In vivo tests on a mouse model showed that GIP reduced tau phosphorylation in the hippocampus, improved memory, and did not affect Aβ plaque levels or neuroinflammation, suggesting a new approach for treating Alzheimer's.
Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice.
Arterioscler Thromb Vasc Biol
September 2024
Article Synopsis
- Dyslipidemia, a risk factor for cardiovascular disease, can be mitigated by time-restricted feeding (TRF), which limits food intake to a 12-hour window, resulting in reduced weight gain and cholesterol levels in preclinical mouse models.
- In studies involving mice with LDLR mutations, TRF significantly decreased hypercholesterolemia and atherosclerosis by promoting lipid metabolism and excretion, demonstrating potential benefits for heart health.
- The findings suggest that TRF could serve as an effective lifestyle intervention for reducing cardiovascular risks, particularly in individuals with LDLR-related conditions, though it may not be effective for those lacking the ApoE protein.
Although fasting is increasingly applied for disease prevention and treatment, consensus on terminology is lacking. Using Delphi methodology, an international, multidisciplinary panel of researchers and clinicians standardized definitions of various fasting approaches in humans. Five online surveys and a live online conference were conducted with 38 experts, 25 of whom completed all 5 surveys.
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