Publications by authors named "M V Maslova"
Article Synopsis
- Transketolase (TKT) is a key enzyme that relies on thiamine (vitamin B1), playing a significant role in brain metabolism related to neurodegenerative diseases.
- In experiments with rats, the enzyme showed altered acylation patterns when thiamine metabolism was disrupted, indicating how different conditions affect TKT activity and modification.
- Specific changes in TKT acylation, particularly malonylation and acetylation at certain sites, were linked to TKT activity differences depending on whether thiamine transporters or ThDP-dependent pathways were inhibited, suggesting a complex relationship between thiamine metabolism and enzyme function.
Pentylenetetrazole-Induced Seizures Are Increased after Kindling, Exhibiting Vitamin-Responsive Correlations to the Post-Seizures Behavior, Amino Acids Metabolism and Key Metabolic Regulators in the Rat Brain.
Int J Mol Sci
August 2023
Article Synopsis
- Epilepsy is linked to an imbalance between the neurotransmitters glutamate and GABA, leading to increased seizure activities in the brain, which were analyzed using a rat model during pharmacological kindling with PTZ.
- Post-seizure findings showed significant changes, including increased levels of p53 and decreased activity in the 2-oxoglutarate dehydrogenase complex, impacting glutamate degradation and leading to protein acetylation changes.
- The administration of vitamins B1 and B6 influenced these biochemical parameters, modifying correlations between seizure severity and neurotransmitter levels, suggesting potential neuroprotective effects against epilepsy-related seizures.
Individual titanium and calcium-magnesium phosphates are widely known as effective sorbents. The sorption processes on these phosphates are based on different mechanisms. The sorption efficiency towards different cations depends on the phase composition of the sorbent.
View Article and Find Full Text PDFAim To determine specific clinical characteristics caused by a combination of the rs397516037 pathogenic variant in the myosin-binding protein C (MTBPC3) and the rs749628307 polymorphic variant in the vinculin (VCL) gene in a Russian family of carriers and to evaluate the contribution of the rs749628307 polymorphic variant in the VCL gene to the development of hypertrophic cardiomyopathy (HCMP).Material and methods The family under study included one healthy person and 3 patients with HCMP. A targeted analysis of proband's exome was performed.
View Article and Find Full Text PDFLithium compounds are of high interest to many industries. The presence of undesirable impurities in Li precursors leads to uncontrolled change in the functional properties of final compounds. Therefore, the development of reliable methods for lithium salt purification is considered a key factor for their application in various industries.
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