Publications by authors named "M V Kovalchuk"

Article Synopsis
  • A rare case of motor neuron disease primarily affecting the lower motor neurons at a single level of the pyramidal tract is examined, focusing on an asymmetric lesion at the cervical level.
  • The study details the patient's clinical symptoms, additional test results, and ongoing monitoring.
  • The article highlights the MRI findings described as "snake eyes" and discusses their significance in diagnosing and predicting the progression of the disease.
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This research introduces an innovative framework for addressing the escalating issue of greenhouse gas emissions through the integration of game theory with differential equations, proposing a novel model to simulate the regulatory dynamics between emission sources and legislative actions. By blending advanced mathematical modeling with environmental science, this paper underscores the critical necessity for pioneering, proactive strategies in environmental management and policy formulation. Central to our approach is the simulation of interactions within a game-theoretic context, aiming to delineate optimal strategies for emission sources and regulatory bodies, factoring in legislative constraints and environmental ramifications.

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X-ray imaging of virus particles at the European XFEL could eventually allow their complete structures to be solved, potentially approaching the resolution of other structural virology methods. To achieve this ambitious goal with today's technologies, about 1 ml of purified virus suspension containing at least 10 particles per millilitre is required. Such large amounts of concentrated suspension have never before been obtained for enveloped viruses.

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Objective: The aim of this study is to elaborate a valid and reliable Russian version of the ALSFRS-R.

Methods: Russian adaptation of the ALSFRS-R was applied twice in 50 ALS patients followed by the test-retest analysis with a 7-day interval between applications and internal consistency analysis.

Results: Test-retest analysis showed very strong correlation for all of the ALSFRS-R variables.

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A model for the transition from disordered liquid state to the solid phase has been proposed based on establishing a correlation between the concentration of precursor clusters in a saturated solution and the features of solid phase formation. The validity of the model has been verified experimentally by simultaneously studying the oligomeric structure of lysozyme protein solutions and the peculiarities of solid phase formation from these solutions. It was shown that no solid phase is formed in the absence of precursor clusters (octamers) in solution; perfect monocrystals are formed at a small concentration of octamers; mass crystallization is observed with an increasing degree of supersaturation (and concentration of octamers); further increase in octamer concentration leads to the formation of an amorphous phase.

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