[Evaluation of the severity course and prognosis of disseminated intravascular blood coagulation syndrome].

Activation of the peroxidal oxidation of lipids (POL) processes with its primary and secondary products levels raising constitutes a favourable sign, according to data of examination of 66 patients, suffering different phases of disseminated intravascular blood coagulation syndrome (DIBCS). The POL products contents reduction (areactive course) characterizes the process severity and constitutes an unfavourable prognostical sign. The areactive course rate is the highest in the patients, suffering DIBCS, phase III.

[Proinflammatory cytokines and tumours necrosis factor level change in bleeding of different genesis].

At investigation of 30 patients with peptic ulcer complicated by gastrointesinal bleeding and 16 injured persons with trauma, covering with blood loss, the disseminated intravascular blood coagulation syndrome revealed in 20 and 37.5% of them accordingly. At both groups revealed the proinflammatory cytokines and tumours necrosis factor-alpha level increased, especially expressed at patients with disseminated intravascular blood coagulation syndrome and trauma with blood loss.

[Effect of pentosan polysulphate (SP-54) on the level of prion physiological form in rat tissues].

It is established that except for already known influence of pentosan polysulphate (SP-54) on the expression of pathological prion, this preparation has an inhibiting effect in respect of physiological prion. Moreover, the reduction of concentration of physiologycal prion is registered in the central and peripheral organs of the prion-replicating system. It was also shown that inhibition of the studied protein leads to the growth in copper and zinc concentration in the proper organs and tissues, but at the same time activity of Cu/Zn-dependent superoxide dismutase does not change.

[Enzyme activity in the blood serum as a criterion of the severity of acute cholecystopancreatitis].

The activity of lactate dehydrogenase, gamma-glutamyltranspeptidase, alkaline phosphatase, 1-antitrypsin was studied in 30 patients with acute cholecystopancreatitis of different severity grades. It was found that changes of activity of these enzymes depending on the severity of the disease may be considered as a criterion of regression of the inflammatory changes in the biliary-pancreatic zone as well as a criterion of recovery.

[The diagnosis and treatment of patients with acute intermittent porphyria].

Four patients with acute intermittent porphyria (AIP) were treated and followed-up. It was established that in AIP urinary pigments have specific absorption spectra in the visible light range. Clinical manifestation and the severity of the disease course correlated with the amount of excretion of copro- and uroporphyrin and their characteristic spectrum of light absorption.