Publications by authors named "M V Khvostov"
Article Synopsis
- The research focuses on finding effective agents against coronaviruses, specifically by synthesizing thiazolo-thiophenes based on usnic acid to inhibit SARS-CoV-2's main protease.
- Certain modifications of the thiophene groups showed moderate antiviral activity, while others had no effect, with kinetic parameters evaluated for the most promising compound.
- The most active compound exhibited strong binding to the protease and effective antiviral activity against various SARS-CoV-2 strains, aligning molecular dynamics results with experimental findings.
Despite the long history of use and the knowledge of the genetics and biochemistry of , problems are still possible in obtaining a soluble form of recombinant proteins in this system. Although, soluble protein can be obtained both in the cytoplasm and in the periplasm of the bacterial cell. The latter is a priority strategy for obtaining soluble proteins.
View Article and Find Full Text PDFArticle Synopsis
- Type 2 diabetes mellitus (T2DM) is a widespread chronic disease, and despite existing treatments, their side effects necessitate the search for new diabetes drugs.
- This study tested two compounds, QS-528 and QS-619, on a diet-induced T2DM model in animals, finding that QS-619 effectively lowered blood sugar levels while QS-528 offered liver protection.
- The research revealed that both compounds activate the free fatty acid receptor-1 (FFAR1), potentially working as full agonists and enhancing insulin and glucose-dependent hormones in mice.
Article Synopsis
- FFAR1 agonists are being researched as potential treatments for type 2 diabetes due to their ability to lower blood sugar levels without causing hypoglycemia.
- The study involved synthesizing seven new compounds as structural analogs, modifying a previously developed FFA1 receptor agonist to investigate their effects on blood sugar regulation.
- The novel compounds demonstrated activation of FFAR1 and increased glucose uptake in liver cells without toxicity, with two specific compounds showing significant hypoglycemic effects in glucose tolerance tests on mice.