Publications by authors named "M V Gordeev"
Article Synopsis
- Anderson-Fabry disease (AFD) is caused by a lack of enzyme activity that leads to the buildup of substances in the body's cells, leading to serious cardiovascular issues, especially hypertrophic cardiomyopathy (HCM).
- This report presents three new cases of obstructive HCM in patients with AFD, where the condition was only diagnosed after surgery through genetic and morphological tests.
- The findings suggest that surgical myectomy can be safe and effective for AFD-related HOCM, highlighting the importance of better screening for AFD symptoms in HOCM patients.
Objective: To establish the criteria for reversibility of myocardial contractility in patients with coronary artery disease (CAD) after coronary artery bypass grafting considering data of cardiac magnetic resonance imaging (MRI) and echocardiography.
Material And Methods: We studied the results of coronary artery bypass grafting in 186 patients with CAD complicated by reduced left ventricular ejection fraction (<30%). All patients underwent cardiac MRI and echocardiography before surgery.
Article Synopsis
- BOB1 is a transcriptional coactivator that influences immune responses, autoimmunity, and blood cancers by affecting the DNA binding of OCT1 and OCT2.
- The study used a method called EMSA-SELEX-Seq to explore how BOB1 changes DNA sequence preferences, confirming its selectivity for OCT1/2 dimers but also highlighting that monomeric forms are key targets.
- These findings offer deeper insights into BOB1's role in immune regulation and its potential as a target for treating autoimmune diseases and blood cancers.
Contezolid acefosamil (CZA) is an intravenous prodrug of oxazolidinone antibiotic contezolid (CZD). It is being developed to treat infections due to Gram-positive bacteria including multidrug-resistant pathogens, while addressing myelosuppression and neurotoxicity limitations associated with long-term use of this class of antibiotics. In vivo, CZA is rapidly deacylated into its first metabolite MRX-1352, which is then dephosphorylated to release active drug CZD.
View Article and Find Full Text PDFAortic stenosis (AS) is the most commonly diagnosed valvular heart disease, and its prevalence increases with the aging of the general population. However, AS is often diagnosed at a severe stage, necessitating surgical treatment, due to its long asymptomatic period. The objective of this study was to analyze the frequency of AS in a population of cardiovascular patients using echocardiography (ECHO) and to identify clinical factors and features associated with these patient groups.
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