Human Melanoma and Glioblastoma Cells Express Cathepsins Supporting Reovirus Moscow Strain Infection.

This study evaluates the oncolytic potential of the Moscow strain of reovirus against human metastatic melanoma and glioblastoma cells. The Moscow strain effectively infects and replicates within human melanoma cell lines and primary glioblastoma cells, while sparing non-malignant human cells. Infection leads to the selective destruction of neoplastic cells, mediated by functional viral replication.

Does sibling family structure matter in the emotion understanding development in preschoolers?

The objective of the study was to investigate the impact of sibling family structure -including the number of children, age gaps, presence of a twin, sibling position, and gender composition - on emotion understanding and its development in children aged 5-6 years. A total of 409 preschoolers participated. Emotion understanding was assessed using The Test of Emotion Comprehension at the baseline and then again at a 1-year follow-up.

Exploring the use of the perceived stress scale for children as an instrument for measuring stress among children and adolescents: a scoping review.

This review examines the application and findings related to the Perceived Stress Scale for Children (PSS-C) since its development by B. White in 2014. The PSS-C is designed to assess children's perceived stress, focusing on their subjective experience rather than objective stressors.

[THE ROLE OF POSITION PROFILING IN THE MEDICAL STAFF HIRING].

The personnel shortage in domestic medical organizations continues to be a key problem in healthcare. Modern research in the field of personnel policy reflects a predominantly random choice of specialty by a graduate after graduating from a medical university - 30% of young specialists leave the profession, often noting that the specialty «did not suit». There is a growing need for job profiling in order to more effectively distribute personnel in various sectors of economic activity.

Not EF skills but play with real toys prevents screen time tantrums in children.

Limiting children's screen time has become a new parenting challenge. Due to the high attractiveness of media and digital devices, many children experience painful transitions in screen time to other activities. Screen time tantrums is a new concept that describes children's negative affect screen time limits.