Toward Biomass-Based Organic Electronics: Continuous Flow Synthesis and Electropolymerization of -Substituted Pyrroles.

Pyrroles are foundational building blocks in a wide array of disciplines, including chemistry, pharmaceuticals, and materials science. Currently sourced from nonrenewable fossil sources, there is a strive to explore alternative and sustainable synthetic pathways to pyrroles utilizing renewable feedstocks. The utilization of biomass resources presents a compelling solution, particularly given that several key bulk and fine chemicals already originate from biomass.

Results of hypofractionated stereotactic radiotherapy for resected and intact large brain metastases.

Unlabelled: Post-resection or isolated hypofractionated stereotactic radiotherapy (HF-SRT) is a therapeutic option for large brain metastases (>2 cm, LBMs).

Objective: To compare the results of post-resection or isolated HF-SRT in patients with LBMs.

Material And Methods: A prospective study included 115 patients with 129 intact LBMs and 133 patients with 149 resected LBMs who underwent HF-SRT.

Navigating α-Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets.

Parkinson's disease is a yet incurable, age-related neurodegenerative disorder characterized by the aggregation of small neuronal protein α-synuclein into amyloid fibrils. Inhibition of this process is a prospective strategy for developing a disease-modifying treatment. We overview here small molecule, peptide, and protein inhibitors of α-synuclein fibrillization reported to date.

New classification and approaches to the treatment of schwannomatosis.

Schwannomatoses is a new classification unit for all the hereditary diseases caused by chromosome 22 damage followed by multiple benign neoplasms of the peripheral and central nervous system. Schwannomatosis occurs as a result of damage to different genes: NF2, SMARCB1, LZRT1, loss of heterozygosity of the long arm of chromosome 22. Nevertheless, clinical manifestations are similar.

Comparison of methods of treatment of meningiomas invading the superior sagittal sinus.

Unlabelled: There are various approaches to the treatment of patients with parasagittal meningiomas.

Objective: To optimize treatment strategy for meningiomas invading the superior sagittal sinus.

Material And Methods: The study included 87 patients with benign parasagittal meningiomas between 2010 and 2012.