Publications by authors named "M V Castellanos"
Background: Thrombopoietin receptor agonists (TPO-RAs) have demonstrated efficacy in treating clinically significant thrombocytopenia, including chemotherapy-induced thrombocytopenia in adults. However, data regarding their safety and efficacy in pediatric, adolescents, and young adult (AYA) patients with hematologic malignancies are limited.
Methods: We retrospectively identified 15 pediatric and AYA patients aged 25 years or younger with hematologic malignancies treated with a TPO-RA at UCSF Benioff Children's Hospitals between 2015 and 2023.
Background: Transmission of requires adequate contact between an infectious case and a susceptible host. The aim of this analysis was to validate a recently developed contact score that assessed settings of exposure and relationships between the case and contact.
Methods: In a cross-sectional study from Kampala, Uganda, we estimated the prevalence of tuberculous infection (TBI) in social contacts of adult TB cases according to the setting and relationship domains of the contact score.
The blood enzyme glutamate-oxaloacetate transaminase (GOT) has been postulated as an effective therapeutic to protect the brain during stroke. To demonstrate its potential clinical utility, a new human recombinant form of GOT (rGOT) was produced for medical use. We tested the pharmacokinetics and evaluated the protective efficacy of rGOT in rodent and non-human primate models that reflected clinical stroke conditions.
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- A comprehensive understanding of the healthcare system and neurology departments is essential for effectively implementing anti-amyloid antibody treatments in hospitals, especially regarding the organization and patient care.* -
- A survey of department heads from 16 Spanish hospitals showed consensus on the need for structural changes, such as focusing Alzheimer’s patients in specialized dementia units and expanding neurology services by hiring more staff and enhancing diagnostic procedures.* -
- The findings underscore the necessity for significant transformations in Spanish neurology departments to ensure the successful integration of anti-amyloid antibodies and promote fair access to new therapies for patients.*