Publications by authors named "M V Castell"
Article Synopsis
- Newborns have an underdeveloped immune system, making them vulnerable to infections like rotavirus (RV), which is a major cause of child mortality, especially in developing countries.
- Maternal immunity plays a crucial role in providing protection against RV through pregnancy and breastfeeding, and this study investigates how enhancing maternal diet can boost newborn immunity.
- Pregnant rats receiving a specific synbiotic showed pups with reduced RV infection severity and elevated levels of immune-related antibodies, indicating that this dietary intervention improves the pups' ability to fight off infections.
Some of the growth factors present in breast milk, such as transforming growth factor-β (TGF-β), epidermal growth factor (EGF) and fibroblast growth factor 21 (FGF21), play important roles in the development of the intestinal tract. The aim of this study was to determine the effect of a supplementation with TGF-β2, EGF and FGF21 on suckling rats intestinal maturation. For this purpose, Wistar rats were supplemented daily with TGF-β2, EGF or FGF21 throughout the suckling period.
View Article and Find Full Text PDFImmunonutrition, which focuses on specific nutrients in breast milk and post-weaning diets, plays a crucial role in supporting infants' immune system development. This study explored the impact of maternal supplementation with M-16V and a combination of short-chain galacto-oligosaccharide (scGOS) and long-chain fructo-oligosaccharide (lcFOS) from pregnancy through lactation, extending into the early childhood of the offspring. The synbiotic supplementation's effects were examined at both mucosal and systemic levels.
View Article and Find Full Text PDFIntroduction: Maternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal disorders. This study focused on the immunomodulatory effects of M-16V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosachairdes (lcFOS), including systemic and mucosal compartments and milk composition.
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