Publications by authors named "M V Cannizzaro"
Background: The relationship between particulate matter (PM) exposure and melanoma risk remains largely unexplored. This study aims to investigate the association between PM10 and PM2.5 long-term exposure and melanoma risk.
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- Cervical cancer still has a poor prognosis despite treatment advances, especially for patients progressing after chemotherapy and immunotherapy, where traditional options are limited.
- Antibody-drug conjugates (ADCs), like tisotumab vedotin, show promise for recurrent/metastatic cervical cancer, demonstrating improved response rates and progression-free survival in trials.
- Key unresolved issues include the optimal timing for ADC use, combination therapy strategies to combat resistance, and managing specific toxicities, with a future focus on biomarker-driven patient selection to enhance treatment effectiveness and safety.
IgG-k/IgG-λ Para-Osseous Plasmacytoma Relapsed as Soft-Tissue Plasmacytoma with IgA-k Immunophenotype: A Case Report and Review of the Literature on Related Biochemical Aspects.
Hematol Rep
August 2024
Article Synopsis
- * The case study highlights a patient with relapsed-refractory EMD who initially presented with a para-osseous plasmacytoma that later evolved into a soft-tissue plasmacytoma with different immunoglobulin characteristics.
- * The authors propose a link between immunoglobulin patterns and patient prognosis, suggesting that these biochemical markers could be integrated into overall risk assessments for the disease.
A knowledge of the complex phenomena that regulate T1 signal on Magnetic Resonance Imaging is essential in clinical practice for a more effective characterization of pathological processes. The authors review the physical basis of T1 Relaxation Time and the fundamental aspects of physics and chemistry that can influence this parameter. The main substances (water, fat, macromolecules, methemoglobin, melanin, Gadolinium, calcium) that influence T1 and the different MRI acquisition techniques that can be applied to enhance their presence in diagnostic images are then evaluated.
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- Multiple sclerosis (MS) is a diverse condition with varying symptoms and treatment responses, prompting a study on its genetic causes related to disease activity over time.
- Researchers analyzed genetic data from two groups of relapsing-remitting MS patients, examining their genomes and specific gene interactions in brain and lymphocyte tissues to identify key genetic variants and pathways involved in MS.
- The study found 23 genetic variants and 223 associated genes, with significant genes such as PON2 and ILRUN linked to oxidative stress and immune modulation, revealing shared and tissue-specific mechanisms driving MS disease activity.