[The relationship between inflammatory markers, fatigue, and effort-based decision-making in patients at clinical high risk for psychosis].

Objective: To evaluate the associations between peripheral levels of inflammatory markers and willingness to exert effort in individuals at clinical high risk for psychosis (CHR-P) and a role of fatigue as a mediator of these associations.

Material And Methods: Forty-nine young men admitted for a depressive episode, who met the criteria for CHR-P, had pre-treatment blood tests to determine levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukins IL-6, IL-8 and IL-10. After treatment and normalization of their condition, they completed the EEfRT task of willingness to exert physical effort to receive monetary reward and filled out the Fatigue Assessment Scale (FAS-10).

[Polymorphic variants in the cluster of genes encoding trace amine receptors and cognitive functioning in patients with schizophrenia spectrum disorders and healthy controls].

Objective: To evaluate the association of polymorphisms in the gene cluster on chromosome 6 with cognitive functions in patients with schizophrenia spectrum disorders and healthy controls.

Material And Methods: Patients with schizophrenia spectrum disorders (=216) and healthy people without a family history of mental disorders (=240) completed a battery of cognitive tests, from which individual indices of cognitive functioning were derived. Associations of the cognitive index with 22 polymorphisms in the genes were assessed using ANCOVA controlling for sex, age, genetic structure of the sample, and polygenic risk scores of schizophrenia and intelligence.

[Willingness to expend effort for rewards in individuals at clinical high-risk for psychosis: a relationship with the severity and stability of negative symptoms].

Objective: To identify the deficit in willingness to expend effort and its association with negative symptoms in the high-risk for psychosis (CHR) group.

Material And Methods: The study included young men: 45 patients, who met CHR criteria and were treated for a depressive episode, and 15 controls. All subjects completed a modified version of the Effort Expenditure for Rewards Task (EEfRT).

[Effects of oxytocin pathway gene polymorphisms and adverse childhood experiences on emotion recognition in schizophrenia spectrum disorders].

Objective: To study a role of the interaction of oxytocin pathway gene polymorphisms and adverse childhood experiences (ACE) in facial emotion recognition (FER) deficits in schizophrenia.

Material And Methods: Patients with schizophrenia spectrum disorders (699) completed cognitive testing, which included a FER task. We determined patients' genotypes for common polymorphisms in three of the oxytocin pathway genes which were previously associated with face perception: (rs53576, rs7632287), (rs3796863) and (rs4778599).