Evaluating the role of active TGF-β1 as inflammatory biomarker in Kashmiri (North-Indian) patients with systemic sclerosis: a case-control study.

Background: As a master immune system regulator, transforming growth factor β1 (TGF-β1) is closely linked to the complicated pathophysiology and development of systemic sclerosis (SSc), a multisystem fibrotic disease.

Objective: We aim to evaluate the transcriptional levels of TGF-β1 mRNA in PBMCs, assess the TGF-β1 serum levels of SSc patients, and compare them with those of healthy subjects.

Methods: PBMCs were isolated from whole blood of 50 SSc patients and in 30 healthy controls.

Fabrication and evaluation of chondroitin sulfate based hydrogels loaded with chitosan nanoparticles for oral delivery of vildagliptin.

Vildagliptin is a drug of choice in type II diabetes mellitus that suffers from limitations like short half-life with reduced bioavailability. To improve the therapeutic performance of vildagliptin, this study aimed to synthesize chitosan nanoparticles (NPs) loaded hydrogel by using biological polysaccharides like sodium alginate (SA) and chondroitin sulfate (CS). The NPs were prepared by ionic gelation method and various characterization tests like surface morphology, size and zeta potential, entrapment efficiency, and in-vitro drug release studies were performed.

3D MFA: An automated 3D Multi-Feature Attention based approach for spine segmentation using a multi-stage network pruning.

Spine segmentation poses significant challenges due to the complex anatomical structure of the spine and the variability in imaging modalities, which often results in unclear boundaries and overlaps with surrounding tissues. In this research, a novel 3D Multi-Feature Attention (MFA) model is proposed for spine segmentation. The standard MobileNetv3 is modified by adding the RCBAM (Reverse Convolution Block Attention Module) module, and FPP (Feature Pyramid Pooling) for feature enhancement.

Role of mordants in natural fabric dyeing and their environmental impacts.

The textile industry is undergoing a transformative shift towards sustainability, driven by mounting environmental concerns and consumer demand for eco-friendly products. This review article explores the use of mordants in textile dyeing processes, encompassing both traditional metal mordants and emerging bio-mordants. Metal mordants, commonly used in textile dyeing, present environmental challenges due to their toxic nature.