Publications by authors named "M Ulldemolins"
Article Synopsis
- Patients undergoing elective pelvic exenteration surgery are at risk of getting inadequate concentrations of the antibiotics piperacillin and tazobactam during surgery.
- This study aimed to analyze how these antibiotics are processed in the body (pharmacokinetics) and to find better dosing recommendations to ensure effective levels during surgery.
- Results showed that a lower continuous infusion dosage of piperacillin/tazobactam is effective in maintaining proper antibiotic levels, but patients with higher weights and kidney function might need higher doses to avoid suboptimal exposure.
Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients (BEATLE): a randomized, multicentre, open-label, superiority clinical trial.
Clin Microbiol Infect
October 2024
Article Synopsis
- The study aimed to evaluate whether extended infusions (EI) of β-lactam antibiotics are more effective than intermittent infusions (II) in treating febrile neutropenia, a condition common in patients receiving chemotherapy and stem cell transplants.
- In a clinical trial involving 150 patients from four Spanish hospitals, those receiving EI experienced a slightly lower success rate at day 5 compared to those on II (50.6% vs. 63.0%), although not statistically significant.
- The research concluded that routine use of EI for β-lactams in this patient group is not supported, suggesting the need for further studies to address the diverse clinical aspects of febrile neutropenia.
Introduction: The evaluation of integrated care programmes for older people is a challenge. We aim to share the early implementation results of the ProPCC programme in the North-Barcelona metropolitan area, in Catalonia, Spain.
Methods: We analysed the intervention with retrospective data from May 2018 to December 2021 by describing the cohort complexity and by showing its 6-months pre-post impact on time spent at home and resources used: primary care visits, emergency department visits, hospital admissions and hospital stay.
Background: The optimisation of the use of β-lactam antibiotics (BLA) via prolonged infusions in life-threatening complications such as febrile neutropenia (FN) is still controversial. This systematic review and meta-analysis aim to evaluate the efficacy of this strategy in onco-haematological patients with FN.
Methods: A systematic search was performed of PubMed, Web of Science, Cochrane, EMBASE, World Health Organization, and ClinicalTrials.
Article Synopsis
- Device-related infections are tough to treat because of biofilms, which protect bacteria, making traditional antibiotic studies less effective, particularly against multi-drug-resistant strains like Pseudomonas aeruginosa.
- This study evaluated the effectiveness of meropenem, a commonly used antibiotic, in fighting these biofilms by comparing two dosing methods: intermittent bolus and extended infusion, particularly with and without the addition of colistin.
- Results indicated that the extended infusion method was more effective for both susceptible and resistant strains of P. aeruginosa, as it significantly enhanced bactericidal activity, especially when combined with colistin, suggesting an optimal treatment strategy.