Publications by authors named "M Ukita"

Article Synopsis
  • Ovarian clear cell carcinoma (OCCC) arises from benign endometriotic cysts and is characterized by poor treatment outcomes, particularly in advanced stages due to resistance to standard therapies and oxidative stress.
  • This study found that OCCC cells are resistant to ferroptosis (a type of cell death linked to iron and oxidative stress) even though they experience oxidative stress, indicating a unique survival mechanism.
  • The research suggests that activating the YAP1 protein, which is regulated by ZDHHC7, may enhance ferroptosis in OCCC cells, highlighting a potential new approach for treating this aggressive cancer.
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Article Synopsis
  • Hypersensitivity reactions (HSRs) to chemotherapy, particularly carboplatin, are significant adverse events that can affect cancer drug therapy, prompting a study on desensitization methods.
  • The study included 136 patients with gynecological cancers undergoing carboplatin desensitization therapy between 2016 and 2020, tracking their treatment responses and HSR symptoms.
  • Findings revealed a 75% success rate for desensitization, with common symptoms like erythema and itching, while no deaths occurred during the study, indicating the need for awareness of potential HSRs.
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There is no consensus on the use of hormone replacement therapy (HRT) after treatment of advanced corpus cancer. We report a case of advanced corpus cancer at a young age, in which HRT was initiated 7 years after surgery, and regional lymph node recurrence was later detected. The patient was 35 years old at the time of initial treatment in X year, when she was diagnosed with stageIIIC2 corpus cancer and underwent a hysterectomy with bilateral salpingo-oophorectomy and a retroperitoneal lymphadenectomy.

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Para-ovarian cysts are occasionally encountered in clinical practice; however, malignant tumors derived from them are rare. Due to its rarity, the characteristic imaging findings of para-ovarian tumors with borderline malignancy (PTBM) are largely unknown. Herein, we report a case of PTBM, along with imaging findings.

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Locally advanced cervical squamous cell carcinoma is a rare indication for surgery. In this report, we describe the case of a patient with presumed locally advanced cervical squamous cell carcinoma who underwent surgical treatment and was postoperatively diagnosed with endometrial cancer with prominent squamous differentiation. A 41-year-old woman presented with squamous cell carcinoma that was detected via Pap smear and confirmed by histological diagnosis of cervical biopsy.

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