Publications by authors named "M Uga"
Objectives: We aimed to identify independent factors for intraoperative endoscopic lens cloudiness during gastric and colorectal endoscopic submucosal dissections, investigate the effectiveness of Cleastay, an endoscope anti-fog solution, and examine factors associated with severe submucosal fat deposition.
Methods: A total of 220 patients who underwent gastric or colorectal endoscopic submucosal dissections in two institutions between January 2022 and October 2023 were included. Significant factors related to cloudiness were determined using univariate and multivariate analyses.
Significance: The advancement of multichannel functional near-infrared spectroscopy (fNIRS) has enabled measurements across a wide range of brain regions. This increase in multiplicity necessitates the control of family-wise errors in statistical hypothesis testing. To address this issue, the effective multiplicity ( ) method designed for channel-wise analysis, which considers the correlation between fNIRS channels, was developed.
View Article and Find Full Text PDFVitamin D hydroxylation in the liver/kidney results in conversion to its physiologically active form of 1,25-dihydroxyvitamin D [1,25(OH)D]. 1,25(OH)D controls gene expression through the nuclear vitamin D receptor (VDR) mainly expressed in intestinal epithelial cells. Cytochrome P450 (CYP) 24A1 is a catabolic enzyme expressed in the kidneys.
View Article and Find Full Text PDFGrowth hormone (GH) exerts multiple effects on different organs directly or via its main mediator, insulin-like growth factor1 (IGF1). In this study, we focused on the novel relationship between GH action and the antiaging hormone α-klotho. Immunofluorescent staining of α-klotho was observed in the renal distal tubules and pituitary glands of somatostatin- and GH-positive cells in wild-type (WT) mice.
View Article and Find Full Text PDFArticle Synopsis
- Adults with food-protein-induced enterocolitis syndrome (FPIES) can experience severe abdominal symptoms, especially after consuming seafood, but no food elimination strategies have been studied for them.
- A retrospective study of 117 seafood-allergic adults found that 22 had FPIES, who exhibited distinct symptoms such as abdominal distention, nausea, and vomiting, particularly related to bivalves like oysters.
- The findings suggest important differences between FPIES and immediate-type food allergies, with many FPIES patients able to safely consume most seafood species aside from the triggers, despite the challenges in achieving tolerance.