Evaluation of the effects of carbamazepine-loaded chitosan-coated PLGA-Zein nanoparticles on pilocarpine-induced seizure model in zebrafish larvae: Developmental toxicity and behavioral assays.

Epilepsy, the most common neurological disorder worldwide, is characterized by sudden paroxysmal brain activity, which can be generalized or focal. Extensive research has explored various treatment strategies for this condition. Our study employed a pilocarpine (PL)-induced seizure model in zebrafish (Danio rerio) embryos and larvae to assess the effects of carbamazepine (CBZ)-loaded chitosan-coated PLGA-Zein nanoparticles (NPs) over 96 hours.

A comparative study of detomidine delivery via intranasal or intramuscular routes in calves undergoing disbudding.

Objective: To compare the sedative and physiological effects of intranasal (IN) and intramuscular (IM) delivery of detomidine in calves.

Study Design: Prospective, randomized experimental study.

Animals: A total of 20 healthy calves, aged 15.

Evaluation of HOTAIR, HOXD8, HOXD9, HOXD11 gene expression levels in Turkish patients with acute and chronic myeloid leukemia: A single center experience.

Homeobox (HOX) transcript antisense RNA (HOTAIR) and HOX genes are reported to be more expressed in various cancers in humans in recent studies. The role of HOTAIR and HOXD genes in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) is not well known. In this study, expression levels of HOXD8, HOXD9 and HOXD11 from HOXD gene family and HOTAIR were determined from peripheral blood samples of 30 AML and 30 CML patients and 20 healthy volunteers by quantitative Real Time PCR.

The assessment of the relationship between the development of cardiovascular diseases and SCUBE-1 level in individuals exposed to loud noise.

Development of industry in the modern world, the number of individuals working in noisy environments is increasing with each passing day. Noise causes an increase in the incidence of cardioembolic events, yet the relevant underlying pathophysiology remains unclear. In this study, we aimed to investigate the relationship between signal peptide and complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein-1 (SCUBE-1) in the pathophysiology of cardioembolic events in individuals exposed to noisy environments.

Resilience and the Dynamics of Job Demands: A Diary Study on Interactions in Healthcare Professionals During the COVID-19 Pandemic.

Aim(s): To explore the day-level interactions between challenge and hindrance job demands and their effects on work engagement and emotional exhaustion among healthcare professionals, focusing on the moderating role of resilience.

Design: A longitudinal, diary-based design was employed.

Methods: This study utilised a multilevel modelling approach to analyse 351 diary entries from 85 healthcare professionals, collected during the COVID-19 pandemic (in March-April 2021).