Immunohistochemical Analysis of the p53 Protein in Colorectal Cancer: A Clinicopathological Study.

The role of p53 expression in colorectal cancer (CRC) was investigated in this immunohistochemical analysis of 110 CRC patients. The study aimed to explore the relationship between p53 expression and clinicopathological features, such as tumor grade, size, lymph node involvement, and molecular subtypes. The mean age of patients was 52.

Dissemination of clinical harboring the gene in Pakistan.

Background: Colistin is an antibiotic used as a last resort to treat multidrug-resistant Gram-negative bacterial infections. Plasmid-mediated mobile colistin-resistant () genes in () are disseminated globally and are considered to be a major public health threat. This study aimed to determine the molecular characteristics of colistin-resistant isolates in clinical settings in Pakistan.

Successful Use of a Midline Catheter for Leukapheresis in Patients Undergoing Collection for Immune Effector Cell Therapy, Donor Lymphocyte Infusion, and Hematopoietic Progenitor Cell Collection.

Apheresis is essential to conducting hematopoietic cell transplantation and genetically engineered cellular therapy procedures. Many patients and donors require central venous catheter (CVC) access for apheresis due to lack of adequate peripheral venous access. CVC placement has risks of associated complications and requires additional institutional resources and expertise.

Lattice Strain-Modulated Trifunctional CoMoO Polymorph-Based Electrodes for Asymmetric Supercapacitors and Self-Powered Water Splitting.

Developing efficient, multifunctional electrodes for energy storage and conversion devices is crucial. Herein, lattice strains are reported in the β-phase polymorph of CoMoO within CoMoO@CoO heterostructure via phosphorus doping (P-CoMoO@CoO) and used as a high-performance trifunctional electrode for supercapacitors (SCs), hydrogen evolution reaction (HER), and oxygen evolution reaction (OER) in alkaline electrolytes. A tensile strain of +2.

Effect of human chorionic gonadotropin on oocyte maturation and developmental competence in buffalo.

We hypothesized that human chorionic gonadotropic (hCG) could replace LH in the maturation media for buffalo oocytes, and hCG administration before ovum pick-up (OPU) enhances in-vitro development of buffalo oocytes. Objectives were 1) to investigate the effect of hCG supplementation on nuclear maturation, oocyte development, and granulosa cell mRNA abundance of genes related to growth and antioxidant pathways and 2) to determine the effect of hCG administration before OPU on in-vitro oocyte development. In Experiment 1, buffalo oocytes retrieved from slaughterhouse ovaries were maturated in the media supplemented with 0.