Publications by authors named "M Tymianski"
Background: In the ESCAPE-NA1 trial (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischemic Stroke), treatment with nerinetide was associated with a smaller infarct volume among patients who did not receive intravenous alteplase. We assessed the effect of nerinetide on the surrogate imaging outcome of final infarct volume in patients who did not receive intravenous alteplase and explored predictors of outcome and modifiers of nerinetide's effect on infarct volume.
Methods: ESCAPE-NA1 was a multicenter, randomized trial in which patients with acute stroke with a baseline Alberta Stroke Program Early CT Score >4, undergoing endovascular thrombectomy, were randomized to receive intravenous nerinetide or placebo.
Article Synopsis
- The study assessed how the quality of reperfusion affects clinical and radiological outcomes in patients from the ESCAPE NA1 trial.
- Researchers analyzed different reperfusion patterns using the expanded Treatment in Cerebral Infarction (eTICI) Scale to compare patient outcomes, including rates of good or excellent clinical recovery, symptomatic hemorrhage, and death.
- Results showed that higher reperfusion grades were linked to better clinical outcomes and lower mortality rates, regardless of how many attempts were needed to achieve them, or the speed of reperfusion.
Background: A recently published individual participant-level meta-analysis found that EVT alone was not non-inferior to combined intravenous thrombolysis (IVT) and EVT. Our aim was to determine factors that influence physicians' treatment choice of IVT-alone versus EVT-alone versus a combined approach.
Methods: We performed an international, structured, invite-only survey among physicians treating patients presenting with AIS.
Cytoprotective agents in stroke: Still uncertainty in the next frontier.
J Stroke Cerebrovasc Dis
September 2024
Article Synopsis
- Doctors are trying to improve treatment for people who have a type of stroke called acute ischemic stroke (AIS), but some patients still don't get better enough.
- They did a survey to find out how doctors decide to use a special medicine that could help patients with AIS.
- The results showed that many doctors would use this special medicine with stroke treatment if they could, but there was confusion about what to do when the treatments affected each other.
Article Synopsis
- The study explores the connection between infarct volume in acute ischemic stroke patients and their chances of achieving good clinical outcomes based on the modified Rankin Scale (mRS).
- Using data from the ESCAPE-NA1 trial, researchers analyzed how changes in infarct volume influence the probabilities of recovery in 1,099 patients over 24 hours post-treatment.
- Findings indicate a nearly linear relationship between infarct volume and good outcomes up to 250 mL, suggesting that significant reductions in infarct size are necessary to improve chances of recovery, especially as patients with volumes over 250 mL have very low probabilities of good outcomes.