The impact of cold application on pain and comfort during the process of diabetic foot care.

Background And Aim: Given the significance of pain management in the context of diabetic foot ulcer (DFU) care, particularly in terms of ensuring patient adherence to treatment regimens, this study was undertaken to ascertain the impact of cold washing on pain and comfort levels during diabetic foot care.

Methods: A single-blind randomized controlled trial was conducted in the chronic wound care clinic of a teaching and research hospital in the southeastern region of Turkey. The sample consisted of 68 patients, with 34 assigned to the cold application group and 34 assigned to the control group.

An enhanced genetic algorithm solution for itinerary recommendation considering various constraints.

This paper addresses the challenging task of itinerary recommendation for tourists and proposes an approach for suggesting efficient optimal itineraries in Istanbul, based on constraints. The paper presents an enhanced version of the genetic algorithm (GA), which aims to optimize the itineraries considering various constraints and preferences of the tourists. The improvement of the GA involved suggesting a customized fitness function tailored to address the complexities of the tourism problem, considering factors such as distance, time, cost, tourists' budget, and their desired activities and attractions.

Microsatellite instability and somatic gene variant profile in solid organ tumors.

Introduction: Absence of mismatch repair (MMR) genes in tumor cells or errors in the replication repair process may lead to DNA-MMR deficiency and microsatellite instability (MSI) formation. Specific tumor environments where gene variations are observed are believed to be conducive to the formation of MSI. This study aimed to determine the MSI status, MMR protein expression, and somatic mutation profile in solid organ tumors.

Optimizing Grape Quality Through Tillage and Organic Fertilization: A Comprehensive Analysis of Phenolic and Anthocyanin Variability Over Three Years.

Knowing the concentration levels of phenolic compounds and anthocyanins in grape berries plays a key role, as these compounds significantly contribute to the nutritional value and quality of grapes, affecting both health benefits and grape quality. The current study was conducted to investigate how different tillage (disc harrow, chisel, no tillage) and organic fertilizer (Antep radish and broccoli chopped residue, olive blackwater) treatments affect the concentration of these valuable compounds in Royal grape berries over three consecutive years (2020-2022), providing insights into optimal agricultural practices for enhancing grape quality. Our results documented significant variations in phenolic and anthocyanin concentrations across different soil tillage, organic fertilizer treatments and years.

Impact of Specimen Extraction Site and Gallstone Size on Early Postoperative Pain Following Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Study.

Background: Laparoscopic cholecystectomy (LC) is widely performed with generally favorable outcomes, but postoperative pain remains a significant issue, influenced by various factors including the specimen extraction site and gallstone size.

Methods: A prospective randomized controlled study was conducted on 100 patients undergoing LC. Participants were randomized to have the specimen removed through either the epigastric or umbilical trocar.