Publications by authors named "M Tufail"

A major limitation to producing high seed yields in berseem clover (Trifolium alexandrinum L.) is failure to set seed, predominantly due to lack of pollination. Despite the importance of berseem clover as a leading forage legume, the contribution of pollinators to seed set is scarce.

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Probiotics are pivotal in maintaining or restoring the balance of human intestinal microbiota, a crucial factor in mitigating diseases and preserving the host's health. Exploration into Bacteroides spp. reveals substantial promise in their development as next-generation probiotics due to their profound interaction with host immune cells and capability to regulate the microbiome's metabolism by significantly impacting metabolite production.

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Article Synopsis
  • Methanosarcina mazei strain Gö1 is a significant organism in climate research due to its methane production, and a new Ribo-seq protocol was developed to study its protein translation under different nitrogen availability conditions.
  • The study identified and confidently predicted the translation of numerous small open reading frames (ORFs), with validation provided through LC-MS and immunoblotting analyses.
  • A detailed differential analysis revealed that many small ORFs are regulated by nitrogen levels, highlighting their potential physiological roles and the importance of small RNAs in nitrogen metabolism within this archaeal model.
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The MALAT1, a huge non-coding RNA, recently came to light as a multifaceted regulator in the intricate landscape of breast cancer (BC) progression. This review explores the multifaceted functions and molecular interactions of MALAT1, shedding light on its profound implications for understanding BC pathogenesis and advancing therapeutic strategies. The article commences by acknowledging the global impact of BC and the pressing need for insights into its molecular underpinnings.

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Cancer cells undergo significant metabolic reprogramming to support their rapid growth and survival. This study examines important metabolic pathways like glycolysis, oxidative phosphorylation, glutaminolysis, and lipid metabolism, focusing on how they are regulated and their contributions to the development of tumors. The interplay between oncogenes, tumor suppressors, epigenetic modifications, and the tumor microenvironment in modulating these pathways is examined.

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