Area measure of skin conductance in the Concealed Information Test.

Skin conductance (SC) is one of the indices commonly used in the autonomic Concealed Information Test (CIT), but SC amplitude is sometimes difficult to quantify. This study investigated the applicability of SC area to the CIT as an unambiguous measure of SC. Secondary analyses of an existing dataset indicated that SC area could be used to classify examinees according to their knowledge status, although the equivalence of its performance with the SC amplitude was inconclusive.

Selective memory detection: Context-dependent stimulus significance in the concealed information test.

Previous studies have posited that the significance of a crime-relevant item in a question produces differential physiological responses in the Concealed Information Test (CIT). However, this term is equivocal and needs to be clarified in order to strengthen the theoretical underpinnings of the CIT. The present study examined the hypothesis that differential responding depends on the examinee's understanding of which item in a question is relevant to a given context.

Gallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation.

We previously reported that lysine-demethylase 2A (KDM2A), a Jumonji-C histone demethylase, is activated by gallic acid to reduce H3K36me2 levels in the rRNA gene promoter and consequently inhibit rRNA transcription and cell proliferation in the breast cancer cell line MCF-7. Gallic acid activates AMP-activated protein kinase (AMPK) and increases reactive oxygen species (ROS) production to activate KDM2A. Esters of gallic acid, propyl gallate (PG) and epigallocatechin gallate (EGCG), and other chemicals, reduce cancer cell proliferation.

Different psychophysiological responses induced by a stimulus change during the orienting task and the Concealed Information Test.

The orienting response (OR) account of the Concealed Information Test (CIT) posits that physiological responses to CIT items are components of the OR. Physiological variations within a stimulus sequence were investigated in an OR task (Study 1) and the CIT (Study 2). In Study 1, an unexpected increase in tone intensity was introduced after repeated standard tone presentations.