Publications by authors named "M Tsumura"
First-bite syndrome (FBS) is manifested as acute and severe pain in the parotid region occurring at the first bite of a meal. While most cases of FBS arise after surgeries involving the deep lobe of the parotid gland, chemotherapy-induced FBS is extremely rare. Some adverse effects of oxaliplatin resemble FBS, suggesting it may be under-recognized.
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- * A study examined 131 female patients with X-linked dominant incontinentia pigmenti (IP), finding that 36% produced autoantibodies against IFN-α and/or IFN-ω, significantly higher than age-matched controls.
- * The presence of these autoantibodies is linked to an abnormally small thymus and predisposes patients to life-threatening viral infections, while those without these autoantibodies do not face the same risk.
Skull base metastases, including those from small-cell lung carcinoma (SCLC), can present with various syndromes depending on the site of involvement, such as orbital syndrome, parasellar syndrome, middle fossa syndrome, jugular foramen syndrome, and occipital condyle syndrome (OCS). One such example is OCS, which consists of unilateral occipital headache accompanied with ipsilateral hypoglossal palsy. This case report describes a 51-year-old man initially diagnosed with OCS, which led to the discovery of systemic bone metastases from SCLC.
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- A 71-year-old man with diabetes experienced headaches and altered consciousness, leading to the discovery of a pneumocephalus caused by an inverted papilloma in the frontoethmoidal sinus.
- He underwent a simultaneous endoscopic and transcranial surgery using an advanced ORBEYE exoscope, which allowed for effective treatment.
- Post-surgery, the patient's symptoms improved, and there was a notable decrease in the elevated squamous cell carcinoma antigen level, highlighting the need for teamwork and modern techniques in tackling complex sinus issues.
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- Heterozygous STAT1 Gain-of-Function mutations are linked to chronic mucocutaneous candidiasis (CMC) and can lead to various immune disorders like autoimmune diseases and malignancies, with JAK inhibitors showing promise in treatment.
- In a study of five Taiwanese patients, two new STAT1 GOF mutations were discovered, revealing clinical symptoms like CMC and autoimmunity, along with notable changes in immune cell types.
- This research provides key insights into the immune dysregulation seen in STAT1 GOF patients and suggests that baricitinib is safe and effective for treatment, although further studies are needed to understand the underlying mechanisms driving these immune changes.