Work functioning impairment and telework: Influence of family cohabiting situation.

Objectives: To clarify the association between telework with family members at home and work functioning impairment.

Methods: A cross-sectional survey was conducted in 27,036 participants. Having children or cohabitants in need of care at home during telework was considered an exposure factor.

Impact of family cohabitation status and work-from-home on sleep problems among Japanese workers during the COVID-19 pandemic: a cross-sectional study.

Objective: This cross-sectional study examined the impact of family cohabitation status and work-from-home (WFH) on sleep during the COVID-19 pandemic.

Methods: An online survey of 27,036 Japanese workers assessed WFH frequency, family cohabitation, and trouble sleeping to estimate odds ratios (OR) for sleep problems from December 22 to 26, 2020.

Results: In multivariate analysis, WFH had no significant benefit for trouble sleeping ≥3 months.

Association between presenteeism and mistreatment at the workplace during the COVID-19 pandemic in Japan: A one-year prospective cohort study.

Objective: Workers were subject to both presenteeism and workplace mistreatment during the COVID-19 pandemic. We aimed to examine their association during the pandemic in Japan.Methods: An internet-based, one-year prospective cohort study was conducted from 2020 to 2021.

Parental occupational exposure to anticancer drugs and radiation: Risk of fetal loss and physical abnormalities in The Japan Environment and Children's Study.

Background: Many studies have indicated an association between maternal occupational exposure to hazardous agents, such as anticancer drugs and ionizing radiation, and an increased risk of adverse pregnancy outcomes, including stillbirths or miscarriages and physical abnormalities in offspring. However, the effects of recent advancements in protective measures to reduce these risks have not been clarified. Aim To investigate the current impact of parental occupational exposure to anticancer drugs and ionizing radiation on stillbirths or miscarriages as well as physical abnormalities under the circumstances of the developed safety protocols.

Intradomain Allosteric Regulation of Soluble Epoxide Hydrolase by Its Substrates.

Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with epoxide hydrolase activity in the C-terminal domain (C-EH) and lipid phosphate phosphatase activity in the N-terminal domain (N-phos). The C-EH hydrolyzes bioactive epoxy fatty acids such as epoxyeicosatrienoic acid (EET). The N-phos hydrolyzes lipid phosphomonesters, including the signaling molecules of lysophosphatidic acid (LPA).