Publications by authors named "M Tsubota"

Purpose: A peripherally inserted central catheter (PICC) placement often requires ultrasound guidance. Previous studies using an adult blood pressure cuff have suggested that veins do not easily collapse at the tourniquet pressure from diastolic to systolic blood pressure. When inserting a PICC into the basilic vein of the upper arm, a narrow blood pressure cuff should be used as a tourniquet to avoid concealing the puncture site.

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We tested the hypothesis that Ca3.2 T-type Ca channels, which can be rebooted by sulfides from Zn inhibition under physiological conditions, and sulfide-generating enzymes including cystathionine-β-synthase (CBS) would participate in the colitis-related visceral pain in mice treated with 2,4,6-trinitrobenzene sulfonic acid (TNBS). The visceral hypersensitivity following TNBS-induced colitis was abolished by an inhibitor or genetic deletion of Ca3.

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Background: Ultrasound guidance is commonly used for accessing difficult peripheral veins. For successful access, a tourniquet is required for venodilation. Tourniquets decrease the compressibility and increase the diameter of veins; they also obfuscate artery-vein differentiation on ultrasound.

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The synthesis of TaSe ring-shaped crystals displaying the coffee ring effect is investigated. By recrystallizing TaSe microcrystals dissolved in droplets of condensed Se gas, ring-shaped crystals were successfully grown. This novel method for ring formation effectively addressed the issue of connecting the edges of the crystal.

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Reactive sulfur species including sulfides, polysulfides and cysteine hydropersulfide play extensive roles in health and disease, which involve modification of protein functions through the interaction with metals bound to the proteins, cleavage of cysteine disulfide (S-S) bonds and S-persulfidation of cysteine residues. Sulfides over a wide micromolar concentration range enhance the activity of Ca3.2 T-type Ca channels by eliminating Zn bound to the channels, thereby promoting somatic and visceral pain.

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