Publications by authors named "M Trznadel"
Synthetic glucocorticoids (GCs) are used to treat a wide range of human health conditions and as such are frequently detected in the aquatic environment. This, together with the highly conserved nature of the glucocorticoid system across vertebrates means that the potential for biological effects of GCs in fish is relatively high. Here, we found that exposure of zebrafish (Danio rerio) to environmentally relevant concentrations of 4 of the most widely used synthetic GCs (beclomethasone dipropionate, budesonide, fluticasone propionate, and prednisolone), from 0 to 4 days post fertilisation (dpf), resulted in no effects on embryo-larval development or bone and cartilage formation.
View Article and Find Full Text PDFGregarines are a large and diverse subgroup of Apicomplexa, a lineage of obligate animal symbionts including pathogens such as , the malaria parasite. Unlike , however, gregarines are poorly studied, despite the fact that as early-branching apicomplexans they are crucial to our understanding of the origin and evolution of all apicomplexans and their parasitic lifestyle. Exemplifying this, the earliest branch of gregarines, the archigregarines, are particularly poorly studied: around 80 species have been described from marine invertebrates, but almost all of them were assigned to a single genus, .
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- Rising global temperatures due to climate change may worsen the toxic effects of pollutants like pharmaceuticals on wildlife, particularly fish, which are sensitive to environmental temperature changes.
- The study used genetically modified zebrafish to investigate how higher temperatures (increased by 2-5 °C) amplify oxidative stress caused by drugs such as paracetamol, diclofenac, and doxorubicin.
- Findings suggest that risk assessments for chemical toxicity in aquatic life should take into account the impact of temperature, as elevated heat can increase both drug absorption and oxidative stress in fish, posing risks for their health and the environment.
Article Synopsis
- - Antidepressants, particularly the tricyclic drug amitriptyline (AMI), are widely prescribed, raising concerns about their effects on non-target aquatic organisms like fish due to potential environmental exposure.
- - A study using zebrafish revealed that AMI accumulates in their bodies, converts to an active metabolite, and impacts gene expression related to serotonin transport even at low, environmentally relevant concentrations.
- - While higher concentrations of AMI affected fish behavior (like increased hatch rates and decreased movement), the overall low risk to fish populations may be underestimated due to factors like the ongoing increase in prescription rates and the presence of other drugs acting similarly.
Zebrafish embryo assays are used by pharmaceutical and chemical companies as new approach methodologies (NAMs) in developmental toxicity screening. Despite an overall high concordance of zebrafish embryo assays with in vivo mammalian studies, false negative and false positive results have been reported. False negative results in risk assessment models are of particular concern for human safety, as developmental anomalies may be missed.
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