sp. nov., a novel bacterium isolated from stable foams formed in wastewater treatment plants and emended description of the genus .

Three strains, designated as J27, J71 and J72, belonging to the genus , were isolated from stable foams formed in activated sludge wastewater treatment plants (WWTPs) in New South Wales, Australia. Phenotypic and genomic analyses revealed that these strains belong to the family and are closely related to . However, distinct genomic and physiological characteristics, including overall genomic relatedness indices, phylogenomic analysis, genomic metabolic profiles and MALDI-TOF MS (Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry), confirmed their status as a new species.

Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms.

Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to late-stage diagnoses. To improve patient outcomes, early intervention in precursor lesions such as intraductal papillary mucinous neoplasm (IPMN) is crucial. However, early intervention must be balanced against overtreatment of low-risk lesions that are unlikely to progress, underscoring the need to better understand molecular alterations in neoplastic cells and changes in the tumor microenvironment (TME) that drive the progression of IPMNs.

Sexual orientation and daily stress and well-being.

Objective: Stigmatization is believed to contribute to health disparities experienced by lesbian, gay, and bisexual (LGB) adults. However, few studies have examined how stigma shapes the perception and response to daily stress by sexual orientation grouping, an important potential mechanism by which stigma impacts health. This study examined responses of daily stress and well-being by sexual orientation.

Glyoxalase 2 Coordinates de Novo Serine Metabolism.

Phosphoglycerate dehydrogenase (PHGDH) is the first enzyme in de novo Ser biosynthesis. Numerous metabolic pathways rely on Ser as a precursor, most notably one-carbon metabolism, glutathione biosynthesis, and de novo nucleotide biosynthesis. To facilitate proliferation, many cancer cells shunt glycolytic flux through this pathway, placing PHGDH as a metabolic liability and feasible therapeutic target for the treatment of cancer.

CMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia.

Introduction: Cytomegalovirus (CMV) infection is a frequent complication among hematopoietic stem cell transplant (HSCT) recipients. Data regarding CMV reactivation in children in underdeveloped countries is scarce. This is especially notable considering the increasing utilization of haploidentical-related HSCT with the post-transplant cyclophosphamide platform.