Publications by authors named "M Trudeau"
Article Synopsis
- This study is a retrospective cohort analysis aimed at evaluating the effectiveness of advanced imaging in confirming the placement of robotic pedicle screws during lumbar spinal fusion.
- It involved 70 patients who had a total of 354 screws placed, with a staggering 99.2% achieving an acceptable accuracy rating (GRS type A), and no screw-related complications reported.
- The findings suggest that robotic systems can accurately place screws without the need for 3D imaging, which could be reserved for cases with increased clinical concern due to associated radiation and operative time risks.
Inhibition of hERG K channels by verapamil at physiological temperature: Implications for the CiPA initiative.
J Pharmacol Toxicol Methods
December 2024
Article Synopsis
- The CiPA initiative is redefining the role of hERG potassium channel inhibition in predicting drug-induced cardiac arrhythmias like Torsades de Pointes (TdP).
- Using a standard experimental protocol, researchers measured the effects of verapamil on hERG1a channels but faced a low success rate of only 5%.
- A revised protocol improved the success rate to 25% while still providing comparable pharmacological data, making the experiment more practical for future studies.
Purpose: This study aimed to examine the impact of the level of HER2 overexpression on pathologic and clinical outcomes in HER2-positive breast cancer (BC) patients treated with neoadjuvant therapy (NAT).
Methods: Women with Stage II or III HER2-positive BC who received anthracycline-taxane-trastuzumab NAT regimens followed by curative-intent surgery were included. Patients were classified according to tumor HER2 expression into HER2-high (immunohistochemistry (IHC) 3+ or fluorescence in situ hybridization (FISH) HER2/CEP17 ratio ≥5 or HER2 copy number ≥10) and HER2-intermediate (IHC 2+ with HER2/CEP17 ratio ≥2 to <5 or copy number ≥4 to <10).
Article Synopsis
- An analysis of chemotherapy treatments for high-risk early breast cancer compared the standard anthracycline-taxane regimen with the alternative docetaxel and cyclophosphamide (TC).
- The study reviewed data from seven randomized-controlled trials involving nearly 12,000 patients, focusing on disease-free survival (DFS), overall survival (OS), and cardiotoxicity.
- Results showed no significant differences in DFS, OS, or cardiotoxicity between TC and anthracycline-taxane, except for patients with four or more lymph nodes, who benefited more from the anthracycline-taxane treatment.
Purpose: A cross-sectional study was conducted to investigate the feasibility of implementing routine collection of the Euro-Qol 5 dimensions (EQ-5D) questionnaire, to inform drug and health technology reimbursement decision making.
Methods: Women with breast cancer were recruited during scheduled clinic visits to an academic cancer centre. EQ-5D-5L was self-administered using electronic tablets.