Publications by authors named "M Treher"
Article Synopsis
- Treatment with bosentan, an endothelin receptor antagonist for pulmonary arterial hypertension, can lead to temporary liver issues due to its action on bile salt transport mechanisms.
- Bosentan's inhibition of the bile salt export pump (BSEP) contributes to liver damage through bile salt accumulation, worsened by its buildup in liver cells via OATP transport proteins.
- In contrast, the newer drug macitentan has a better liver safety profile, due to its different absorption mechanism and limited interaction with liver bile salt transporters, supported by various studies and trials.
Objectives: Gadoxetic acid [gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA); Primovist] is a liver specific contrast agent for magnetic resonance imaging. For risk assessment of the single diagnostic use the toxicity of this compound was assessed.
Materials And Methods: Studies into acute, repeated-dose, reproductive and developmental toxicity, and local tolerance, contact sensitizing, and genotoxic potential were performed.