Synergies and complementarities between ecosystem accounting and the Red List of Ecosystems.

Safeguarding biodiversity and human well-being depends on sustaining ecosystems. Two global standards for quantifying ecosystem change, the International Union for Conservation of Nature Red List of Ecosystems (RLE) and the United Nations System of Environmental-Economic Accounting Ecosystem Accounting (EA), underpin headline indicators for the Kunming-Montreal Global Biodiversity Framework. We analyse similarities and differences between the standards to understand their complementary roles in environmental policy and decision-making.

De Novo Genome Assemblies From Two Indigenous Americans from Arizona Identify New Polymorphisms in Non-Reference Sequences.

There is a collective push to diversify human genetic studies by including underrepresented populations. However, analyzing DNA sequence reads involves the initial step of aligning the reads to the GRCh38/hg38 reference genome which is inadequate for non-European ancestries. In this study, using long-read sequencing technology, we constructed de novo genome assemblies from two indigenous Americans from Arizona (IAZ).

Pleiotropic effects of an eQTL in the CELSR2/PSRC1/SORT1 cluster that associates with LDL-C and resting metabolic rate.

Context: The locus CELSR2-PSRC1-SORT1, a primary genetic signal for lipids, has recently been implicated in different metabolic processes. Our investigation identified its association with energy metabolism.

Objective: To determine biological mechanisms that govern diverse functions of this locus.

An E115A Missense Variant in CERS2 Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians.

Genetic determinants of interindividual differences in energy expenditure (EE) are largely unknown. Sphingolipids, such as ceramides, have been implicated in the regulation of human EE via mitochondrial uncoupling. In this study, we investigated whether genetic variants within enzymes involved in sphingolipid synthesis and degradation affect EE and insulin-related traits in a cohort of American Indians informative for 24-h EE and glucose disposal rates during a hyperinsulinemic-euglycemic clamp.