Publications by authors named "M Totaro"

Achieving safe influenza vaccination coverage among pregnant and breastfeeding women is a global health goal due to the potential risks of serious influenza for both mother and child. However, vaccine hesitancy remains a significant barrier to vaccination uptake. Since anxiety represents a determinant in vaccine decision-making, this study aimed to assess influenza vaccination hesitancy and anxiety levels in this population and to explore the association between women's characteristics, their reluctance, and anxiety levels.

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The advancement of personalized treatments in oncology has garnered increasing attention, particularly for rare and aggressive cancer with low survival rates like the bone tumors osteosarcoma and chondrosarcoma. This study introduces a novel PDMS-agarose microfluidic device tailored for generating patient-derived tumor spheroids and serving as a reliable tool for personalized drug screening. Using this platform in tandem with a custom imaging index, we evaluated the impact of the anticancer agent doxorubicin on spheroids from both tumor types.

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Article Synopsis
  • The herbicide glyphosate effectively inhibits the enzyme EPSPS, highlighting the shikimate pathway as a target for developing new antimicrobial and herbicidal agents.
  • The final enzyme in this pathway, chorismate synthase (CS), was tested with various azo-dyes, leading to the identification of PH011669 as a significant inhibitor with specific dissociation and inhibition values.
  • The study utilized molecular docking and MD simulations to analyze how PH011669 interacts with CS, providing foundational insights for future development of novel enzyme inhibitors.
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Background: Osteoporosis and metabolic syndrome (MetS) are conditions associated with ageing and chronic inflammation; among MetS' components, visceral obesity has been correlated to low bone mineral density in postmenopausal women. However, data on an increased fracture risk in MetS are still contrasting. The trabecular bone score (TBS) is an indicator of bone quality and a potential predictive factor for fractures.

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