Publications by authors named "M Torrington"
Objective: To determine the independent and combined effects of pain and opioids on the activation of an early marker of inflammation, nuclear factor-κB (NF-κB).
Design: NF-κB activation was compared within-subjects following four randomly ordered experimental sessions of opioid-only (intravenous fentanyl 1 μg/kg), painonly (cold-pressor), opioid + pain, and a resting condition.
Setting: University General Clinical Research Center.
Gamma-hydroxybutyrate (GHB) is a drug with significant abuse potential. The present study aimed to assess the relative value of escalating doses of GHB to current GHB users via the Multiple Choice Procedure (MCP), and to validate that the dose rated highest with the MCP would be self-administered at a greater rate than placebo. Participants were 5 current GHB users who were not currently trying to stop using GHB.
View Article and Find Full Text PDFObjectives: Opioids are the most effective pain medication available, yet concerns about their safety may limit their administration to those in need. In efforts to identify analgesics with lower potential for abuse and dependence, recent evidence suggests that combinations of opioids with ultra-low doses of the opioid antagonist naloxone may enhance the analgesic effect with increased safety. This study investigated the use of buprenorphine (0.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the effectiveness of buprenorphine treatment for opioid dependence across three different settings: an opioid treatment program (OTP), a group counseling program using the Matrix Model, and a private psychiatrist clinic.
- Participants received a year-long buprenorphine treatment, with varied treatment visit schedules, and outcomes were measured based on opioid use, retention in treatment, and participation in counseling.
- Results indicated that while opioid use was consistent across sites, retention rates differed significantly depending on the treatment setting, pointing to the effectiveness of the environment in supporting participant engagement.