Publications by authors named "M Topazian"
Background/objectives: Debilitating abdominal pain is a common symptom affecting patients with chronic pancreatitis (CP). CP pain is dynamic due to multiple underlying mechanisms. The objective of this study was to 1) evaluate changes in pain phenotype at one year follow-up and 2) validate putative pain biomarkers in a prospective cohort study.
View Article and Find Full Text PDFAssociation of Serum Endocannabinoid Levels with Pancreatitis and Pancreatitis-Related Pain.
Cannabis Cannabinoid Res
September 2024
Article Synopsis
- * Results showed women had higher levels of AEA, and obese participants had more PEA, while asymptomatic controls had lower AEA compared to those with pancreatic diseases.
- * Additionally, individuals with acute pancreatitis had the highest AEA levels, but lower 2-AG levels were found in those with recent abdominal pain; these findings suggest potential therapeutic targets related to cannabinoid receptors in managing pancreatitis.
Background: Infections have a poor prognosis in inpatients with cirrhosis. We aimed to determine regional variations in infections and their association with clinical outcomes in a global cohort of inpatients with cirrhosis.
Methods: In this prospective cohort study initiated by the CLEARED Consortium, we enrolled adults (aged >18 years) with cirrhosis who were non-electively admitted to 98 hospitals from 26 countries or regions across six continents between Nov 5, 2021, and Dec 10, 2022.
Background: Ductal features alone may not offer high diagnostic sensitivity or most accurate disease severity of chronic pancreatitis (CP).
Purpose: Diagnose CP based on multiparametric MRI and MRCP features.
Study Type: Prospective.
Article Synopsis
- Atrial fibrillation (AF) ablation can lead to serious complications like esophageal injuries, which can create life-threatening fistulas; EUS (Endoscopic Ultrasound) is being explored as a better diagnostic tool than EGD (Esophagogastroduodenoscopy) for detecting these injuries.
- A study of 234 patients showed that EUS effectively identified various conditions post-ablation, including pleural effusions and esophageal wall changes, with a strong association between certain EUS findings and the severity of esophageal injury.
- The findings suggest that EUS is a safe and potentially superior method for evaluating post-ablation injuries in patients, with recommendations for prioritizing EUS over EGD in these