Publications by authors named "M Tone"

Background: Cancer immunotherapy including immune checkpoint inhibitors is only effective for a limited population of patients with cancer. Therefore, the development of novel cancer immunotherapy is anticipated. In preliminary studies, we demonstrated that tetracyclines enhanced T-cell responses.

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Background: Cryopreservation of porcine oocytes is difficult compared with other species and immature oocytes particularly so compared to the meiotic stage.

Objective: To evaluate the efficacy of a pretreatment with 1 micromole per L paclitaxel (PTX, 30 min exposure) before vitrification to promote the maturation of porcine immature oocytes.

Materials And Methods: Cumulus cell-enclosed oocytes (COs) aspirated from porcine ovaries were divided into three groups: i) non-pretreated with PTX and non-vitrified group (control group); ii) pretreated with PTX and vitrified group (PTX-V group); and iii) non-pretreated with PTX and vitrified group (nPTX-V group).

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Article Synopsis
  • This study explores T cell profiles and functions in lung tissues from non-small cell lung cancer (NSCLC) patients with and without interstitial lung disease (ILD) to understand the risks associated with immunotherapy, specifically immune checkpoint inhibitors (ICIs).
  • Researchers found that NSCLC patients with ILD had higher levels of certain T cell subtypes and immune checkpoint molecules compared to those without ILD, indicating a potentially different immune response.
  • The data suggests that Treg cells could hinder the production of key cytokines, which may contribute to the risk of pneumonitis in patients undergoing immunotherapy, underscoring the need for careful management in these patients.
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Minocycline is often administered prophylactically or therapeutically to non-small cell lung cancer (NSCLC) patients receiving epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) for skin rash as an adverse event. We examined the effects of minocycline on the outcomes of EGFR-mutant NSCLC treated with first-line EGFR-TKIs based on a single-center retrospective analysis. In this retrospective cohort study, data were collected on NSCLC patients treated with first-line EGFR-TKIs between January 2010 and June 2021.

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