Publications by authors named "M Tondelli"
Background: A limited number of studies have investigated the role of environmental chemicals in the etiology of mild cognitive impairment (MCI). We performed a cross-sectional study of the association between exposure to selected trace elements and the biomarkers of cognitive decline.
Methods: During 2019-2021, we recruited 128 newly diagnosed patients with MCI from two Neurology Clinics in Northern Italy, i.
Background: A few studies have suggested that light at night (LAN) exposure, i.e. lighting during night hours, may increase dementia risk.
View Article and Find Full Text PDFObjective: Neurofilament light chain proteins (NfLs) are considered a promising biomarker of neuroaxonal damage in several neurological diseases. Their measurement in the serum and cerebrospinal fluid (CSF) of patients with dementia may be especially useful. Our aim was to compare the NfL measurement performance of two advanced technologies, specifically the Ella™ microfluidic platform and the Lumipulse™ fully automated system, in patients with cognitive disorders.
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- Changes in cholesterol-related factors are important in Alzheimer's disease (AD), but their timing, specific links, and relationship to genetic factors are still unclear.
- The study measured Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) and specific cholesterol metabolites in the cerebrospinal fluid (CSF) and serum of patients with different cognitive decline stages, focusing on AD and mild cognitive impairment (MCI-AD) with respect to genetic carriers.
- Results showed that PCSK9 and certain cholesterol markers in AD patients, especially genetic carriers, could act as specific indicators of lipid changes associated with AD progression, which weren’t observed in MCI-AD patients.
Studies exploring the brain correlates of behavioral symptoms in the frontotemporal dementia spectrum (FTD) have mainly searched for linear correlations with single modality neuroimaging data, either structural magnetic resonance imaging (MRI) or fluoro-deoxy-D-glucose positron emission tomography (FDG-PET). We aimed at studying the two imaging modalities in combination to identify nonlinear co-occurring patterns of atrophy and hypometabolism related to behavioral symptoms. We analyzed data from 93 FTD patients who underwent T1-weighted MRI, FDG-PET imaging, and neuropsychological assessment including the Neuropsychiatric Inventory, Frontal Systems Behavior Scale, and Neurobehavioral Rating Scale.
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