Publications by authors named "M Todaka"
Article Synopsis
- The study investigates HPH-15, a compound that activates AMPK, for its potential as a diabetes treatment, focusing on its ability to manage blood glucose levels and prevent complications.
- Researchers tested HPH-15's effects on glucose uptake and fat accumulation in different cell types and high-fat diet mice, comparing it to the established diabetes drug metformin.
- Results showed HPH-15 improved blood glucose levels and reduced fat accumulation more effectively than metformin, indicating it may be a promising therapeutic option for diabetes management.
Introduction: Cardiovascular disease (CVD) is the leading cause of death in hemodialysis patients (HPs). As a food source, fish contains both CVD-preventive and CVD-promoting fatty acids; however, there is no consensus on fish consumption as a preventive measure for CVD in HPs. This single-center longitudinal cohort study aims to assess the impact of fish intake frequency (FIF) per week on CVD in Japanese HPs.
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- AMPK activation enhances glucose and lipid metabolism, and the ADAM17 inhibitor SN-4 is found to activate AMPK, leading to increased GLUT4 translocation and sugar uptake.
- The AMPK inhibitor dorsomorphin reversed the effects of SN-4, confirming that the benefits come from AMPK activation.
- SN-4 also reduces lipid accumulation in liver cells and inhibits TNF-α release, highlighting its potential as a new antidiabetic drug that manages blood sugar and prevents complications without significant side effects like lactic acidosis.
Introduction: Prader-Willi syndrome is a congenital disorder that occurs in one in 10 000-30 000 children and is characterized by obesity, short stature, and intellectual disability.
Case Presentation: A 24-year-old male patient with Prader-Willi syndrome presented with an enlarged adrenal tumor. Computed tomography detected a well-defined mass.
Recent studies have shown that some people claim that their skin gases provoke allergy-like reactions in people in their near vicinity. Such a phenomenon or symptom is called 'people allergic to me (PATM)'. Although numerous people suffer from PATM, the actual conditions are unknown.
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