Publications by authors named "M Tisljar"
Article Synopsis
- FHR-5 is a protein similar to Factor H, which regulates the immune system's alternative pathway, suggesting it may influence kidney diseases where this pathway is dysfunctional.
- In a study of 120 patients with diagnosed IC-MPGN and C3G, FHR-5 serum levels were measured, and genetic variants were analyzed to understand their role in disease.
- Results indicated that 12.6% of patients had genetic variations and that lower serum levels of FHR-5 correlated with better kidney survival and signs of excessive complement activity, suggesting FHR-5 may be important in the disease process.
Purpose: To assess the effect of receiving a kidney with PUJ dysfunction on the recipient renal graft function.
Methodology: 198 patients, who underwent renal transplantation from 1st January 2004 to 31st December 2014 in a single Center in the North West of England, were retrospectively reviewed using a computerized database. Split kidney function and the PUJ dysfunction for the donors were assessed using Tc-99 m MAG3 renogram.
Background: A novel data-driven cluster analysis identified distinct pathogenic patterns in C3-glomerulopathies and immune complex-mediated membranoproliferative glomerulonephritis. Our aim was to replicate these observations in an independent cohort and elucidate disease pathophysiology with detailed analysis of functional complement markers.
Methods: A total of 92 patients with clinical, histological, complement and genetic data were involved in the study, and hierarchical cluster analysis was done by Ward method, where four clusters were generated.
Background: Acquired or genetic abnormalities of the complement alternative pathway are the primary cause of C3glomerulopathy(C3G) but may occur in immune-complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) as well. Less is known about the presence and role of C4nephritic factor(C4NeF) which may stabilize the classical pathway C3-convertase. Our aim was to examine the presence of C4NeF and its connection with clinical features and with other pathogenic factors.
View Article and Find Full Text PDFAim: To determine the role of immunoglobulin M (IgM) deposits in clinical manifestations, disease outcome, and treatment response of idiopathic and secondary focal segmental glomerulosclerosis (FSGS).
Methods: Kidney biopsy specimens of 171 patients diagnosed with FSGS (primary and secondary) and 50 control patients were retrospectively included in the study. For each patient, clinical and outcome data were obtained and compared to morphological parameters, including immunofluorescence analysis of mesangial IgM and complement 3 (C3) deposits analyzed on kidney biopsy samples.