Publications by authors named "M Tikkanen"
The photosynthetic electron flux from photosystem I (PSI) is mainly directed to NADP and CO fixation, but a fraction is always shared between alternative and cyclic electron transport. Although the electron transfer from P700 to ferredoxin, via phylloquinone and the FeS, FeS and FeS clusters, is well characterized, the regulatory role of these redox intermediates in the delivery of electrons from PSI to NADP, alternative and cyclic electron transport under environmental stress remains elusive. Here we provide evidence for sequential damage to PSI FeS clusters under high light and subsequent slow recovery under low light in Arabidopsis thaliana.
View Article and Find Full Text PDFContext: The decrease in serum estrogens after menopause is associated with a shift from a gynoid to an android adipose tissue (AT) distribution. Menopausal hormone therapy (HT) mitigates this change and accompanying metabolic dysfunction, but its effects on AT sex steroid metabolism have not been characterized.
Objective: We studied effects of HT on subcutaneous and visceral AT estrogen and androgen concentrations and metabolism in postmenopausal women.
Article Synopsis
- The study examined long-term outcomes for women who experienced a maternal stroke, focusing on mortality, recovery, vocational status, and overall health compared to matched stroke-free controls.
- Out of 235 women with maternal strokes studied in Finland from 1987 to 2016, the mortality rate was significantly higher than controls (5.5% vs. 2.4%), but 90.3% of cases retained independence in daily activities after follow-up.
- Women who had a maternal stroke were less likely to be employed and more likely to be on pensions, while also facing higher rates of cardiovascular-related health issues compared to the control group.
Article Synopsis
- The study examines the use of intravenous thrombolysis (IVT) and endovascular thrombectomy for treating ischemic strokes in pregnant women, highlighting a lack of previous research in this area.
- Data was collected from national registers in Finland over nearly three decades, comparing the outcomes of 12 IVT-treated maternal stroke patients to a control group of young females with non-pregnancy-related strokes.
- Results indicate that while IVT-treated patients showed significant neurological improvement, their overall functional outcomes were less favorable compared to controls, suggesting that maternal strokes should not be dismissed from potential recanalization therapies.
Background And Purpose: Intracerebral hemorrhage during pregnancy or puerperium (pICH) is one of the leading causes of maternal death worldwide. However, limited epidemiological data exist on the etiology and outcomes of pICH, which is required to guide prevention and treatment.
Methods: A retrospective nationwide cohort study and a nested case-control study was performed in Finland 1987-2016.