Publications by authors named "M Tihy"
Pancreatic ductal adenocarcinoma (PDAC) tumor interpatient heterogeneity has been well described with two major prognostic subtypes (classical and basal-like). An important intrapatient heterogeneity has been reported but has not yet been studied extensively due to the lack of standardized, reproducible, and easily accessible high-throughput methods. We built an immunohistochemical (IHC) tool capable of differentiating RNA-defined classical and basal-like tumors by selecting relevant antibodies using a multistep process.
View Article and Find Full Text PDFPancreatic neuroendocrine tumours (PanNETs) have intra-tumour heterogeneity, notably regarding the Ki-67 index, which is a major prognostic factor. The temporal evolution of PanNET biology is poorly known. We aimed to study the prognostic impact of the temporal evolution of Ki-67 and other molecular markers (MEN1, ATRX/DAXX and PDX1/ARX) in PanNETs.
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- Ovarian neuroendocrine tumors (NETs) are rare tumors often found in mature teratomas, but there hasn’t been a recent study looking at their characteristics using new tumor markers.
- This study analyzed 34 unilateral NETs, identifying four distinct immunophenotypic profiles and determining the tumors' grade and proliferation rates with specific markers.
- The findings indicate that the most common NET type shows an intestinal phenotype, suggesting a neuroendocrine precursor in the teratoma and emphasizing that these tumors shouldn't be classified based on the surrounding teratoma components.
Article Synopsis
- Alcohol-related liver disease (ALD) affects about 30% of heavy drinkers, characterized by liver damage including steatosis, fibrosis, and steatohepatitis.
- The study investigated the connection between genetic variants of keratins 8 and 18 (KRT8/18) and histological features of ALD in 106 severe cases, finding significant links to specific genetic variants.
- Elevated levels of KRT18 fragments were associated with certain KRT18 variants and alcoholic hepatitis, indicating that these genetic factors may influence the severity and prognosis of ALD.
Background And Aims: Non-alcoholic fatty liver disease (NAFLD) is one of the leading cause of hepatocellular carcinoma (HCC). This association is supported by the translocation of bacteria products into the portal system, which acts on the liver through the gut-liver axis. We hypothesize that portosystemic shunting can disrupt this relationship, and prevent NAFLD-associated HCC.
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