Publications by authors named "M Thoresen"
Environmental exposures, including air pollutants and lack of natural spaces, are associated with suboptimal health outcomes in children. We aimed to study the associations between environmental exposures and gene expression in children. Associations of exposure to particulate matter (PM) with diameter <2.
View Article and Find Full Text PDFImportance: Outcomes after hypoxic-ischemic encephalopathy (HIE) are variable. Predicting death or severe neurodevelopmental impairment (NDI) in affected neonates is crucial for guiding management and parent communication.
Objective: To predict death or severe NDI in neonates who receive hypothermia for HIE.
In recent years, we have been able to gather large amounts of genomic data at a fast rate, creating situations where the number of variables greatly exceeds the number of observations. In these situations, most models that can handle a moderately high dimension will now become computationally infeasible or unstable. Hence, there is a need for a prescreening of variables to reduce the dimension efficiently and accurately to a more moderate scale.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess whether brain MRI after rewarming could help predict specific neurodevelopmental outcomes in 2-year-old infants who underwent hypothermia treatment for brain injuries caused by oxygen deprivation.
- Researchers conducted a multicenter study, analyzing MRI findings and their correlations with outcomes like cerebral palsy, cognitive delays, and other conditions; results were categorized and predicted according to severity and likelihood.
- Out of 152 infants, significant correlations were found between MRI predictions and actual outcomes, such as 90% of those categorized as "highly likely" to develop cerebral palsy did so, showcasing MRI's utility in anticipating developmental challenges.