Complemental hard modeling in Raman spectroscopy: A case study on titanium dioxide-free coating in-line monitoring.

Tablets are coated for taste or odor modification, for modified release profiles or as a protective layer to increase the stability. Here, titanium dioxide is frequently added as a coating component due to its opaque properties. Furthermore, its Raman activity makes it an integral part of in-line monitoring models.

Development and Application of an Advanced Percolation Model for Pore Network Characterization by Physical Adsorption.

Physical adsorption is one of the most widely used techniques to characterize porous materials because it is reliable and able to assess micro- and mesopores within one approach. Challenges and open questions persist in characterizing disordered and hierarchically structured porous materials. This study introduces a pore network model aimed at enhancing the textural characterization of nanoporous materials.

Mechanisms of drug release from a melt-milled, poorly soluble drug substance.

Increasing the dissolution kinetics of low aqueous soluble drugs is one of the main priorities in drug formulation. New strategies must be developed, which should consider the two main dissolution mechanisms: surface reaction and diffusion. One promising tool is the so-called solid crystal suspension, a solid dispersion consisting of purely crystalline substances.

A Monte Carlo simulation of tracer diffusion in amorphous polymers.

Tracer diffusion in amorphous polymers is a sought-after quantity for a range of technological applications. In this regard, a quantitative description of the so-called decoupling from the reverse proportionality between viscosity and diffusion coefficient into a fractional one remains a challenge requiring a deeper insight. This work employs a Monte Carlo simulation framework in 3 dimensions to investigate the consequences of different scenarios for estimating this fractional exponent on the diffusion coefficient of tracers in polymers near glass transition.