Publications by authors named "M Thoenes"
Article Synopsis
- The study conducted the first genome-wide association study (GWAS) on sporadic Alzheimer's disease (AD) using a sample from Argentina and Chile, involving 539 patients and 854 controls.
- Combining their findings with data from the European Alzheimer and Dementia Biobank (EADB), researchers identified apolipoprotein E ε4 as a significant genetic risk factor and discovered four new loci linked to AD.
- The research highlights the shared genetic factors affecting AD risk across different populations, while also noting that a genetic risk score (GRS) showed diminishing effectiveness with increasing Native American ancestry.
Objective: Current guidelines recommend use of heart valve centres (HVCs) to deliver optimal quality of care for patients with valve disease but there is no evidence to support this. The hypothesis of this study is that patient care with severe aortic stenosis (AS) will differ in HVCs compared with satellite centres. We aimed to compare the treatment of patients with AS at HVCs (tertiary care hospitals with full access to AS interventions) to satellites (hospitals without such access).
View Article and Find Full Text PDFThe transcatheter aortic valve implantation (TAVI) treatment pathway is complex, leading to procedure-related delays. Dedicated TAVI coordinators can improve pathway efficiency. COORDINATE was a pilot observational prospective registry at three German centers that enrolled consecutive elective patients with severe aortic stenosis undergoing TAVI to investigate the impact a TAVI coordinator program.
View Article and Find Full Text PDFBackground: The Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ) is a validated instrument for assessing quality of life (QoL) in patients with severe aortic stenosis (AS). In this study, we evaluated health status outcomes, based on the TASQ, in patients with severe AS undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR).
Methods: The TASQ registry was a prospective observational registry.
Background: Degenerative aortic stenosis (AS), the most common valvular heart disease in the Western world, is often diagnosed late when the mortality risk becomes substantial. We determined the feasibility of AS screening during influenza vaccination at general practitioner (GP) surgeries in the UK.
Methods: Consecutive subjects aged >65 years presenting to a GP for influenza vaccination underwent heart auscultation and 2D echocardiography (V-scan).